Launched in 2005, the Empowering Africa’s Young People Initiative (EAYPI) helped prevent the spread of HIV among 10- to 25-year-olds in Tanzania, Uganda, and Zambia. The five-year initiative, supported through the President’s Emergency Plan for AIDS Relief (PEPFAR), and administered by USAID, helped scale up programs proven to promote healthy behaviors. Through EAYPI, IYF supported 13 local youth-serving organizations through on-site mentoring, workshops, seminars, as well as country-specific curricula and technical guidelines. By the program’s close, nearly 33,000 peer educators and parents had trained to share HIV prevention messages, and these messages reached 1.9 million parents and young people.